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This book describes Diabetes Type 3c (Pancreatogenic Diabetes), Diagnosis and Treatment and Related Diseases
Just a week ago I was emailed an article on Pancreatogenic Diabetes
Intrigued I decided to look further into research papers and found that it is not as rare as it appeared.
Pancreatogenic diabetes is a form of secondary diabetes that occurs when pancreatic inflammation, neoplasia, or resection leads to beta-cell dysfunction, affecting the secretion of insulin causing Types 3c Diabetes.
Type 3c diabetes is almost twice as frequent as type 1 diabetes but is misdiagnosed as type 2 diabetes in over 87% of patients.
Type 3c diabetes patients tended about 1.5 times more likely to have poor glycemic control than those with type 2 diabetes and tended almost 10 times more likely to use insulin.
Those with type 3c diabetes need insulin therapy more urgently than those with type 2, so the result of this misdiagnosis are delays in giving proper treatment leading to nerve, eye, and kidney damage.
Causes:
1.Chronic pancreatitis is the most frequent disease of the exocrine pancreas linked with the development of diabetes
2.Cystic fibrosis-related diabetes (CFRD)
3.Lacking genes in the E2F group
4.Finally, other less frequent forms of pancreatogenic diabetes are present, such as that due to pancreatic cancer, and post-pancreatectomy diabetes
Symptoms:
These symptoms are typical of diabetes:
1. Frequent thirst even after drinking lots of water
2. Passing more frequent urine during day and night
3. Weight loss
Most patients with T3cDM have a known history of:
1. Pancreatitis with abdominal pain,
2. Steatorrhea or
3. Mal-digestion
4. Nutritional deficiencies and
5. Glucose intolerance.
Patients may also manifest with symptoms of:
1. Mal-digestion and
2. Abdominal pain
Diagnosis:
The diagnosis of T3cDM requires
1.The evidence of pancreatic exocrine insufficiency (based on monoclonal fecal elastase 1 test)
2.Evidence of pathological pancreatic imaging (by endoscopic ultrasound, MRI)
3.The absence of type 1 diabetes mellitus (T1DM)-linked auto-antibodies
Confirmation of T3cDM can then be made by report of an absent pancreatic polypeptide response to mixed-nutrient ingestion
Treatment:
The treatment of hyperglycemia to reach and maintain the HbA1c 1.Lifestyle Modifications
Alcohol and smoking cessation
High Fiber diet
Pancreatic Enzymes
Vitamin D supplements
2.Anti-Hyper-glyemic Agents
Since the main endocrine defect is insulin deficiency, insulin treatment is the preferred treatment for most patients
The main treatment is to:
a.Correct hyperglycemia for CFRD,
b.For acutely ill or hospitalized patients, and
c.For severely malnourished patients
For not so high blood sugars, oral treatments in the form of a pill or capsule may be given.
In chronic pancreatitis-linked diabetes, when hyperglycemia is mild (HbA1c Metformin is advised as first-line oral therapy for T2DM, a population in which metformin may decrease the risk of pancreatic cancer
Metformin therefore has a hypothetical use in chronic pancreatitis if tolerated due to frequent gastrointestinal adverse effects and weight loss
3.Total Pancreatectomy with Islet Autotransplantation (TPIAT)
TPIAT is regarded as specific treatment of repeat occurrences of acute or chronic pancreatitis for the primary indication of giving pain relief, with anticipated withdrawal of narcotics and relief from repeat hospitalizations to treat pain aggravations
TABLE OF CONTENT
Introduction
Chapter 1 Pancreatogenic Diabetes
Chapter 2 Causes
Chapter 3 Symptoms
Chapter 4 Diagnosis
Chapter 5 Treatment
Chapter 6 Prognosis
Chapter 7 Diabetes Mellitus
Chapter 8 Pancreatitis
Epilogue
ASIN : B077C5HYMP
Publication date : November 10, 2017
Language : English
File size : 417 KB
Text-to-Speech : Enabled
Screen Reader : Supported
Enhanced typesetting : Enabled
X-Ray : Not Enabled
Word Wise : Enabled
Sticky notes : On Kindle Scribe
Print length : 109 pages
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