The methylenetetrahydrofolate reductase gene (MTHFR) is a well-defined example of a gene-nutrient interaction. MTHFR is involved in folic acid metabolism and in maintaining normal levels of homocysteine in the blood. This could be explained by the variation of their genetic polymorphisms, which leads to the emergence of the concept of nutrigenomics and nutrigenetics. The aim of this study is to investigate the influence of the umami taste receptor gene polymorphisms from TAS1R1 (rs1749255) on the food intake of
female students in Mississippi. Dietary
nutrient intake is an important environmental factor, and there are significant differences in the development of cancer between individuals with the same dietary intake. Repeating a butyrate-containing diet for 24 hours significantly increased the binding of BRD4 and CDK9 to the Si and Lph genes compared to the control group. Mendelian randomization (MR) is an approach that allows the causal effects of the risk factor on outcomes to be investigated by using a genetic variant as an instrumental variable. It concludes with a discussion of ethical issues and an appendix for determining sample size in connection with the determination of genetic characteristics in nutritional epidemiology
studies.
Gene expression profiles and DNA methylation at the promoter of the genes zinc transporter (ZIP8, ZIP1) and metallothionein (MT1G, MT1H, MT) were determined by a genome-wide microarray approach. These complex interactions (nutrient regulation of gene transcription, foodborne DNA damage, phytochemical improvement or protection of DNA integrity, genetic vulnerability to diet-related diseases) provide increasing information about the epidemiological links between diet and health and disease. All coding exons and promoter regions for 13 genes as well as single nucleotide polymorphisms (SNPs) in 20 genes associated with SS are captured in the test. The aim of this study was to use a nutrigenomic approach to investigate the expression of certain lipid and lipoprotein genes in order to
elucidate the biological mechanisms.
The ultimate goal of developing this genetic test is future use in cohorts where the SS phenotype has been determined to differentiate responders to low-sodium intake from people who do not respond. We suggest that by modifying DNA methylation, the traditional Korean diet may modulate genes that are associated with metabolic diseases and are strongly correlated with clinical indicators and dietary composition. There is increasing evidence that the way nutrients are metabolically processed is more or less genetically controlled. The aim of this study was to determine whether the degree of divergence between epigenetic age and chronological age is related to habitual diet in a community-based cohort
.
The mRNA expression levels of the disaccharidase genes were determined by a real-time reverse transcriptase polymerase chain reaction and the extent of histone acetylation around the sucrase isomaltase (Si) gene and the lactase phlorizin hydrolase (Lph) gene as well as the binding of the acetylated histone binding protein BRD4, the transcription extension factor CDK9 and cyclin measured T1 were measured by chromatin immunoprecipitation.
References:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265830/
- Nutrient: Gene Interactions – The University of Nottingham