The methods for evaluating gene variations and epigenetic markers are far more sophisticated than the high-throughput methods for studying metabolism. Traditionally, many gene and metabolism studies have used a targeted approach that measured a small amount of metabolites in metabolic pathways that are likely related to a gene alteration. Metabolomic profiling (also known as metabonomic profiling) is so sophisticated that it can be used to simultaneously measure numerous small molecules that are the product of numerous metabolic pathways. mass spectroscopic
(Lawton et al.
These methods offer the opportunity to measure the effects of genes on metabolism more precisely. Because nutrigenomics involves genetic testing that uses samples from identified populations, ethical and legal implications may arise. To meet this challenge, nutrigenomics must assemble a cohort of multidisciplinary scientists who are able to speak their own “language,” develop better methods, and create a comprehensive data set from which the great thinkers among us can develop theory. The contributions address the limits of nutrigenetics, nutrigenomics, epigenetics, transcriptomics as well as with non-coding RNAs
and post-translational gene regulations for various diseases and ailments.
We start with a non-exhaustive list of five different types of uncertainties that end users of nutrigenomics must deal with without being able to perceive them as risks and subject them to a risk analysis. Nutrigenomics is therefore surrounded by internal and external uncertainties, and it is up to end users to better prepare for a future of genomics with fundamental uncertainties than to expect the uncertainties to disappear in the long term. The distinction between nutrigenomics and nutrigenetics is often blurred by various and sometimes contradictory definitions, and both terms are still frequently used interchangeably. Nutrigenomics also makes it possible to study how nutrients are found in humans
Influence the genome of existing genes.
For example, with the knowledge of nutrigenomics, a person diagnosed with cardiovascular disease can change their dietary intake to lower their low-density lipoprotein levels and increase their high-density lipoprotein levels in their body to prevent and minimize the effects of CVD on their body. In addition, nutrigenomics is also concerned with the search for markers for the early phase of diet-related diseases. The challenge will be to adapt these methods so that they are validated for use in nutrigenomic studies
Can.